Having some resist disease/poison enchantments give you some protection, so if you run across any, use them. Also, anything that reflects damage is fantastic. You can equip it and then watch lower-class enemies such as rats and mud crabs kill themselves when they attack you because the damage reflects back on them. Unfortunately you cannot enchant things with reflect damage or spells, but you can find things in dungeons sometimes, or get them as rewards for quests, so be on the lookout.
Seriously. I once had about 66% reflect damage (total, of three enchanted things), and when rats would jump on me, they would die within three jumps. Same for mud crabs. Goblins would take a little longer, but if I kept my health up while they attacked, it would be fun to watch them eventually kill themselves. Or bandits or highwaymen. The list goes on.